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Health ArticlesKnow about onion skin periosteal reaction with Ewing sarcoma

Know about onion skin periosteal reaction with Ewing sarcoma


When it comes to⁤ understanding medical conditions, it ‌is ⁢important to be ⁣aware ‍of the various symptoms and signs ‍associated with them. One such condition is Ewing sarcoma, a rare type of bone cancer that primarily affects children and young adults. In⁣ the early stages⁢ of Ewing ⁢sarcoma, ​one of the⁤ common indicators is the presence of ​onion⁢ skin periosteal reaction. In this article, we will‌ delve into ⁤the definition, causes, detection, seriousness, and other signs of Ewing ‌sarcoma, specifically focusing‍ on ⁤the onion skin periosteal ​reaction.

onion skin periosteal reaction with Ewing sarcoma
onion skin periosteal reaction with Ewing sarcoma


Onion skin periosteal‌ reaction ⁤refers ⁤to a radiological finding seen in⁤ certain ‌bone diseases, ⁢particularly Ewing sarcoma. This condition is characterized ⁣by the formation of ‌multiple thin ⁤layers ​of new bone around the affected bones, resembling the layers of an onion. When observed on imaging studies, such as ⁣X-rays or CT scans, the bone⁣ affected by Ewing⁤ sarcoma exhibits‍ a distinct​ appearance that resembles the​ concentric circles of ‌an onion skin.

Causes with ⁤Ewing sarcoma

Ewing ⁣sarcoma is a malignant ⁣tumor that arises in ‌the bones or soft tissues. It mainly affects children ‍and⁢ young⁣ adults between the ages of 10 and 20. The exact ⁤cause of‍ Ewing sarcoma is still unknown, but it⁢ is ‍thought ⁢to ​be related​ to genetic mutations in the cells of ⁣the bone marrow. ⁢These mutations result in the uncontrolled growth of‌ cells, leading ⁣to the formation of‌ tumors. The onion skin periosteal reaction is a specific radiological manifestation seen in Ewing sarcoma, indicating⁤ the aggressive nature of ⁣the tumor and its effects on ‍the bone structure.


The presence of onion skin periosteal reaction can be detected through imaging studies, such as X-rays, CT scans, or MRI. When ⁢a suspicious bone lesion is found, these imaging techniques can provide a clear visualization ⁢of the affected area. X-rays‍ may‌ show the characteristic concentric​ onion skin appearance, while CT scans or MRI can ‍provide ‌more detailed ‌information about the⁢ size, location, and extent of the tumor. It is essential to consult with a medical professional,⁤ such as ⁣an oncologist or ⁣orthopedic⁢ surgeon, for accurate interpretation and diagnosis.

Is it serious?

The onion skin periosteal reaction in Ewing‌ sarcoma is indeed ​a ⁣serious finding. Ewing sarcoma ⁣is​ a highly⁢ aggressive cancer that requires prompt treatment to improve the prognosis. The presence of onion skin ​periosteal reaction suggests⁢ that the tumor has invaded the bone, leading to the formation of new bone layers as a response. This reaction ⁣indicates⁣ an active and fast-growing tumor, ‍emphasizing the importance of early detection ⁤and intervention.

Other signs of Ewing sarcoma

Apart from onion skin periosteal reaction,⁤ there are other signs and symptoms associated with Ewing sarcoma. ‍These may include ‌bone pain, swelling,⁢ tenderness, fatigue, weight loss, and fever. Since these ⁤symptoms can be nonspecific⁣ and may resemble other⁣ conditions, it is crucial to consult a‍ healthcare‍ professional ⁢for a⁢ comprehensive evaluation and accurate diagnosis.

Other causes

While onion⁤ skin periosteal‍ reaction is strongly associated with Ewing sarcoma, it is ⁢not exclusive to‍ this ‌condition.⁣ Other bone diseases, such⁢ as⁤ osteomyelitis (bone infection), osteosarcoma ‍(a type ⁢of bone cancer),⁣ or ⁢neuroblastoma ‍(a cancer that can⁢ spread⁣ to the bones) ‍can also cause⁢ a similar reaction. Therefore, a ⁢thorough‌ evaluation‌ by⁤ a medical expert is required to differentiate between these conditions and determine the appropriate treatment approach.


Onion skin periosteal reaction ​is a radiological finding commonly seen in⁢ Ewing sarcoma, a rare type of bone ‌cancer. This concentric onion skin appearance ​indicates ⁣the aggressive ⁢nature ‍of the⁣ tumor‍ and its impact on the⁤ affected bone. Prompt detection and accurate diagnosis are crucial in treating Ewing sarcoma ​effectively. Other signs and​ symptoms, such⁣ as bone ‍pain and swelling, may accompany this condition, further emphasizing the need⁤ for medical evaluation.‌ While onion skin periosteal⁢ reaction strongly suggests Ewing⁣ sarcoma, other bone diseases‍ can potentially cause a similar ‌reaction, necessitating the assistance of a healthcare ⁣professional for precise ‌diagnosis and ⁤treatment.


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